Publications

2018

Dharmaraj, K.; Nasri, Z.; Kahlert, H.; Scholz, F. : The electrochemistry of DPPH in three-phase electrode systems for ion transfer and ion association studies, Journal of Electroanalytical Chemistry (2018). doi10.1016/j.jelechem.2018.06.012.[Epub ahead of print]

Nowak, K.; Taubert, R. M.; Haberecht, S.; Venz, S.; Krüger, E. : Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition, Bioscience Reports (2018) 38, doi 10.1042/BSR20180393. [Epub ahead of print]

Imber, M.; Pietrzyk-Brzezinska, A. J.; Antelmann, H. : Redox regulation by reversible protein S-thiolation in Gram-positive bacteria, Redox Biology (2018) 20, 130–145. doi10.1016/j.redox.2018.08.017.[Epub ahead of print]

Imber, M.; Huyen, N. T. T.; Pietrzyk-Brzezinska, A. J.; van Loi, V.; Hillion, M.; Bernhardt, J.; Tharichen, L.; Kolsek, K.; Saleh, M.; Hamilton, C. J.; Adrian, L.; Grater, F.; Wahl, M. C.; Antelmann, H. Protein S-Bacillithiolation Functions in Thiol Protection and Redox Regulation of the Glyceraldehyde-3-Phosphate Dehydrogenase Gap in Staphylococcus aureus Under Hypochlorite Stress, Antioxidants & Redox Signaling (2018) 28, 410–430. doi 10.1089/ars.2016.6897.

Imber, M.; van Loi, V.; Reznikov, S.; Fritsch, V. N.; Pietrzyk-Brzezinska, A. J.; Prehn, J.; Hamilton, C.; Wahl, M. C.; Bronowska, A. K.; Antelmann, H. The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S-bacillithiolation in Staphylococcus aureus, Redox Biology (2018) 15, 557–568. doi 10.1016/j.redox.2018.02.001.

Laporte, A.; Nordenbrock, A.; Lenzen, S.; Elsner, M. Light-induced intracellular hydrogen peroxide generation through genetically encoded photosensitizer KillerRed-SOD1, Free Radical Research (2018), doi 10.1080/10715762.2018.1540042. [Epub ahead of print]

Mayerle, J.; Kalthoff, H.; Reszka, R.; Kamlage, B.; Peter, E.; Schniewind, B.; González Maldonado, S.; Pilarsky, C.; Heidecke, C.-D.; Schatz, P.; Distler, M.; Scheiber, J. A.; Mahajan, U. M.; Weiss, F. U.; Grützmann, R.; Lerch, M. M. Metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis, Gut (2018) 67, 128–137. doi 10.1136/gutjnl-2016-312432.

Morlock, L.; Grobe, S.; Balke, K.; Mauersberger, S.; Böttcher, D.; Bornscheuer, U. : Protein Engineering of the Progesterone Hydroxylating P450‐Monooxygenase CYP17A1 Alters its Regioselectivity, ChemBioChem (2018), 1954–1958. doi 10.1002/cbic.201800371.

Morlock, L. K.; Böttcher, D.; Bornscheuer, U. T. Simultaneous detection of NADPH consumption and H2O2 production using the Ampliflu™ Red assay for screening of P450 activities and uncoupling, Applied Microbiology and Biotechnology (2018) 102, 985–994. doi 10.1007/s00253-017-8636-3.

Neumann-Schaal, M.; Metzendorf, N. G.; Troitzsch, D.; Nuss, A. M.; Hofmann, J. D.; Beckstette, M.; Dersch, P.; Otto, A.; Sievers, S. : Tracking gene expression and oxidative damage of O2-stressed Clostridioides difficile by a multi-omics approach, Anaerobe (2018). doi 10.1016/j.anaerobe.2018.05.018.[Epub ahead of print]

Ohlig, T.; Le, D. V.; Gardemann, A.; Wolke, C.; Gürtler, S.; Peter, D.; Schild, L.; Lendeckel, U. Effects of siRNA-dependent knock-down of cardiolipin synthase and tafazzin on mitochondria and proliferation of glioma cells, Biochimica et Biophysica Acta (2018) 1863, 379–387. doi 10.1016/j.bbalip.2018.01.003.

Reisky, L.; Stanetty, C.; Mihovilovic, M. D.; Schweder, T.; Hehemann, J.-H.; Bornscheuer, U. T. : Biochemical characterization of an ulvan lyase from the marine flavobacterium Formosa agariphila KMM 3901T, Appl Microbiol Biotechnol (2018). doi 10.1007/s00253-018-9142-y.[Epub ahead of print]

Reisky, L.; Büchsenschütz, H. C.; Engel, J.; Song, T.; Schweder, T.; Hehemann, J.-H.; Bornscheuer, U. T. Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases, Nature Chemical Biology (2018) 14, 342-344. doi 10.1038/s41589-018-0005-8.

Sendler, M.; Weiss, F.-U.; Golchert, J.; Homuth, G.; van den Brandt, C.; Mahajan, U. M.; Partecke, L.-I.; Döring, P.; Gukovsky, I.; Gukovskaya, A. S.; Wagh, P. R.; Lerch, M. M.; Mayerle, J. Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice, Gastroenterology (2018) 154, 704-718.e10. doi 10.1053/j.gastro.2017.10.018.

2017

Ahrens, P.; Zander, M.; Hasse, U.; Wulff, H.; Jeyabharathi, C.; Kruth, A.; Scholz, F. Electrochemical Formation of Gold Nanoparticles on Polycrystalline Gold Electrodes during Prolonged Potential Cycling, ChemElectroChem (2017) 35, 8699. doi 10.1002/celc.201700745.

Beyer, G.; Mahajan, U. M.; Budde, C.; Bulla, T. J.; Kohlmann, T.; Kuhlmann, L.; Schütte, K.; Aghdassi, A. A.; Weber, E.; Weiss, F. U.; Drewes, A. M.; Olesen, S. S.; Lerch, M. M.; Mayerle, J. Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts, Gastroenterology (2017) 153, 1544-1554.e2. doi 10.1053/j.gastro.2017.08.073.

Heise, N.; Scholz, F. Assessing the effect of the lipid environment on the redox potentials of the coenzymes Q 10 and Q 4 using lipid monolayers made of DOPC, DMPC, TMCL, TOCL, and natural cardiolipin (nCL) on mercury, Electrochemistry Communications (2017) 81, 141–144. doi 10.1016/j.elecom.2017.07.002.

Hillion, M.; Imber, M.; Pedre, B.; Bernhardt, J.; Saleh, M.; van Loi, V.; Maaß, S.; Becher, D.; Astolfi Rosado, L.; Adrian, L.; Weise, C.; Hell, R.; Wirtz, M.; Messens, J.; Antelmann, H. The glyceraldehyde-3-phosphate dehydrogenase GapDH of Corynebacterium diphtheriae is redox-controlled by protein S-mycothiolation under oxidative stress, Scientific Reports (2017) 7, 5020. doi 10.1038/s41598-017-05206-2.

Isabettini, S.; Massabni, S.; Kohlbrecher, J.; Schuler, L. D.; Walde, P.; Sturm, M.; Windhab, E. J.; Fischer, P.; Kuster, S. Understanding the Enhanced Magnetic Response of Aminocholesterol Doped Lanthanide-Ion-Chelating Phospholipid Bicelles, Langmuir (2017) 33, 8533–8544. doi 10.1021/acs.langmuir.7b01370.

Möller, D*.; Gellert, M.*; Langel, W.; Lillig, C. H. Molecular dynamics simulations and in vitro analysis of the CRMP2 thiol switch, Molecular BioSystems (2017) 13, 1744–1753. doi 10.1039/c7mb00160f.

Plötz, T.; Krümmel, B.; Laporte, A.; Pingitore, A.; Persaud, S. J.; Jörns, A.; Elsner, M.; Mehmeti, I.; Lenzen, S. The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human beta cells, Nutrition & Diabetes (2017) 7, 305. doi 10.1038/s41387-017-0005-x.

Tassler, S.; Wölk, C.; Janich, C.; Dobner, B.; Brezesinski, G. Lysine-based amino-functionalized lipids for gene transfection, Physical Chemistry Chemical Physics (2017) 19, 20271–20280. doi 10.1039/C7CP03107F.

Thal, D. A.; Kahlert, H.; Jeyabharathi C.; Ahrens, P.; Hasse, U. Impact of gold 1-decanethiol-SAM formation and removal cycles on the surface properties of polychristalline gold and SAM quality, Journal of Solid State Electrochmistry (2017),1-6. doi.org/10.1007/s10008-017-3858-y.

2016

Gröning, A.; Ahrens, H.; Ortmann, T.; Lawrenz, F.; Helm, C. A. Polyetylenimine (PEI) adsorption to a DMPG lipid-monolayer in the presence of iron salts and EDTA, Polymer (2016) 102, 386–395. doi 10.1016/j.polymer.2016.08.034.

Gurgul-Convey, E.; Mehmeti, I.; Plötz, T.; Jörns, A.; Lenzen, S. Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines, Diabetologia (2016) 59, 2125–2133. doi 10.1007/s00125-016-4060-y.

Hoernke, M.; Tassler, S.; Koksch, B.; Brezesinski, G. Membrane binding of peptide models for early stages of amyloid formation, Chemistry and Physics of Lipids (2016) 198, 28–38. doi 10.1016/j.chemphyslip.2016.02.010.

Janich, C.; Taßler, S.; Meister, A.; Hause, G.; Schäfer, J.; Bakowsky, U.; Brezesinski, G.; Wölk, C. Structures of malonic acid diamide/phospholipid composites and their lipoplexes, Soft Matter (2016) 12, 5854–5866. doi 10.1039/C6SM00807K.

Jeyabharathi, C.; Ahrens, P.; Hasse, U.; Scholz, F. Identification of low-index crystal planes of polycrystalline gold on the basis of electrochemical oxide layer formation, Journal of Solid State Electrochemistry (2016) 20, 3025–3031. doi 10.1007/s10008-016-3228-1.

Mahajan, U. M.; Teller, S.; Sendler, M.; Palankar, R.; van den Brandt, C.; Schwaiger, T.; Kühn, J.-P.; Ribback, S.; Glöckl, G.; Evert, M.; Weitschies, W.; Hosten, N.; Dombrowski, F.; Delcea, M.; Weiss, F.-U.; Lerch, M. M.; Mayerle, J. Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer, Gut (2016) 65, 1838–1849. doi 10.1136/gutjnl-2016-311393.

Malla, S. R.; Kärrman Mårdh, C.; Günther, A.; Mahajan, U. M.; Sendler, M.; D'Haese, J.; Weiss, F. U.; Lerch, M. M.; Hansen, M. B.; Mayerle, J. Effect of oral administration of AZD8309, a CXCR2 antagonist, on the severity of experimental pancreatitis, Pancreatology (2016) 16, 761–769. doi 10.1016/j.pan.2016.07.005.

Perfahl, S.; Natile, M. M.; Mohamad, H. S.; Helm, C. A.; Schulzke, C.; Natile, G.; Bednarski, P. J. Photoactivation of Diiodido-Pt(IV) Complexes Coupled to Upconverting Nanoparticles, Molecular Pharmaceutics (2016) 13, 2346–2362. doi 10.1021/acs.molpharmaceut.6b00108.

Plötz, T.; Hartmann, M.; Lenzen, S.; Elsner, M. The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells, Nutrition & Metabolism (2016) 13, 16. doi 10.1186/s12986-016-0076-z.

Rebl, H.; Finke, B.; Schmidt, J.; Mohamad, H. S.; Ihrke, R.; Helm, C. A.; Nebe, J. B. Accelerated cell-surface interlocking on plasma polymer-modified porous ceramics, Materials Science & Engineering. C, Materials for Biological Applications (2016) 69, 1116–1124. doi 10.1016/j.msec.2016.08.016.

Sahr, A.; Wolke, C.; Maczewsky, J.; Krippeit-Drews, P.; Tetzner, A.; Drews, G.; Venz, S.; Gürtler, S.; van den Brandt, J.; Berg, S.; Döring, P.; Dombrowski, F.; Walther, T.; Lendeckel, U. The Angiotensin-(1-7)/Mas Axis Improves Pancreatic β-Cell Function in Vitro and in Vivo, Endocrinology (2016) 157, 4677–4690.
doi 10.1210/en.2016-1247.

Sendler, M.; Maertin, S.; John, D.; Persike, M.; Weiss, F. U.; Krüger, B.; Wartmann, T.; Wagh, P.; Halangk, W.; Schaschke, N.; Mayerle, J.; Lerch, M. M. Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis, The Journal of Biological Chemistry (2016) 291, 14717–14731. doi 10.1074/jbc.M116.718999.

Tanasescu, R.; Lanz, M. A.; Mueller, D.; Tassler, S.; Ishikawa, T.; Reiter, R.; Brezesinski, G.; Zumbuehl, A. Vesicle Origami and the Influence of Cholesterol on Lipid Packing, Langmuir  (2016) 32, 4896–4903. doi 10.1021/acs.langmuir.6b01143.

2015

Berg, F.; Wilken, J.; Helm, C. A.; Block, S. AFM-based quantification of conformational changes in DNA caused by reactive oxygen species, The Journal of Physical Chemistry B (2015) 119, 25–32. doi 10.1021/jp507659x.

Gehrmann, W.; Würdemann, W.; Plötz, T.; Jörns, A.; Lenzen, S.; Elsner, M. Antagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells, Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology (2015) 36, 852–865. doi 10.1159/000430261.

Gellert, M.; Hanschmann, E.-M.; Lepka, K.; Berndt, C.; Lillig, C. H. Redox regulation of cytoskeletal dynamics during differentiation and de-differentiation, Biochimica et Biophysica Acta (2015) 1850, 1575–1587. doi 0.1016/j.bbagen.2014.10.030.

Muschiol, J.; Peters, C.; Oberleitner, N.; Mihovilovic, M. D.; Bornscheuer, U. T.; Rudroff, F. Cascade catalysis-strategies and challenges en route to preparative synthetic biology, Chemical Communications (Cambridge, England) (2015) 51, 5798–5811. doi 10.1039/c4cc08752f.

Romero, J. I.; Hanschmann, E.-M.; Gellert, M.; Eitner, S.; Holubiec, M. I.; Blanco-Calvo, E.; Lillig, C. H.; Capani, F. Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia, Biochimica et Biophysica Acta (2015) 1850, 1274–1285. doi 10.1016/j.bbagen.2015.02.015.

Schmidt, S.; Scherkus, C.; Muschiol, J.; Menyes, U.; Winkler, T.; Hummel, W.; Gröger, H.; Liese, A.; Herz, H.-G.; Bornscheuer, U. T. An enzyme cascade synthesis of ε-caprolactone and its oligomers, Angewandte Chemie (International ed. in English) (2015) 54, 2784–2787. doi 10.1002/anie.201410633.

Sendler, M.; Beyer, G.; Mahajan, U. M.; Kauschke, V.; Maertin, S.; Schurmann, C.; Homuth, G.; Völker, U.; Völzke, H.; Halangk, W.; Wartmann, T.; Weiss, F.-U.; Hegyi, P.; Lerch, M. M.; Mayerle, J. Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis, Gastroenterology (2015) 149, 765-76.e10. doi 10.1053/j.gastro.2015.05.012.

van Loi, V.; Rossius, M.; Antelmann, H. Redox regulation by reversible protein S-thiolation in bacteria, Frontiers in Microbiology (2015) 6, 187.
doi 10.3389/fmicb.2015.00187.

2014

Janich, C.; Wölk, C.; Taßler, S.; Drescher, S.; Meister, A.; Brezesinski, G.; Dobner, B.; Langner, A. Composites of malonic acid diamides and phospholipids – Structural parameters for optimal transfection efficiency in A549 cells, European Journal of Lipid Science and Technology (2014) 116, 1184–1194.
doi 10.1002/ejlt.201300405.

Jeyabharathi, C.; Hasse, U.; Ahrens, P.; Scholz, F. Oxygen electroreduction on polycrystalline gold electrodes and on gold nanoparticle-modified glassy carbon electrodes, Journal of Solid State Electrochemistry (2014) 18, 3299–3306. doi 10.1007/s10008-014-2657-y.